Original Articles: Drug Allergy, Insect Sting Allergy, and Anaphylaxis
            Drug allergies, insect sting allergies, and anaphylaxis are severe
            allergic reactions that pose significant health risks worldwide.
            Drug allergies occur when the immune system reacts adversely to
            medications, leading to symptoms ranging from mild rashes to
            life-threatening anaphylaxis. Common culprits include antibiotics,
            nonsteroidal anti-inflammatory drugs (NSAIDs), and chemotherapy
            agents. Insect sting allergies, triggered by the venom of bees,
            wasps, hornets, or ants, can also result in severe reactions and
            anaphylaxis, characterized by difficulty breathing, swelling, and a
            sudden drop in blood pressure.
            
          
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                HLA-A*02:01 Presents Penicillin-Modified Cysteinylated Peptides for T Cell RecognitionS. J. R. Goh, H. H. W. Lu, K. E. Scull, et al. Allergy. First published: 04 September 2025
 
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                Deciphering Immune Endotypes Within Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) SyndromeC. von Wachter, M. Ameri, T. Chimbetete, et al. Allergy. First published: 23 June 2025
 
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                Direct Single-Dose Drug-Provocation Test Is Safe for Delabelling Penicillin Low-Risk Reactions in AdultsLabella, M., Rodriguez de Guzmán, J., Diez-Echave, P., et al. Allergy. First published:16 May 2025
 
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                The Discrepancy Between Perceived and Proven Drug Hypersensitivity in a Well-Defined Cohort of Patients With Inborn Errors of ImmunityBilgic-Eltan, S., Karakurt, T., Yuksel, R.G., et al.Allergy. First published:29 April 2025
 
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                Targeting the Galectin-7/TRPM2/Zn2+/DRP-1 Signaling Pathway: A Potential Therapeutic Intervention in the Pathogenesis of SJS/TENZhang, C., Pang, B., Luo, Y., et al. Allergy. First published: 05 March 2025
 
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                Discrepancies in Beta-Lactam Antibiotics Cross-Reactivity: Implications for Clinical PracticeHutten, E.M., Bulatović Ćalasan, M., Trubiano, J.A., et al. Allergy. First published: 21 February 2025
 
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                Basophil Activation Test Positivity Decreases With Time in Immediate Allergic Reactions to Proton Pump InhibitorsFernandez-Santamaria, R., Salas, M., Ariza, A., et al. Allergy. First published: 27 November 2024
 
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                Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergySun L, Zhao Q, Ao S, et al. Allergy. First published: 11 November 2024
 
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                Basophil activation test is a complementary tool in the diagnosis of immediate reactions to platinum salts and taxanesBogas G, Ariza A, Vázquez-Revuelta P, et al. Allergy. First published: 31 August 2024
 
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                Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE4 excretionMastalerz L, Trąd G, Szatkowski P, et al. Allergy. First published: 23 August 2024
 
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                Impact of a drug allergy education course for non-specialists: Findings from ADAPT—A randomized crossover trialLucas M, Mak HWF, Lee JTY, Kulkarni R, Chan SSC, Li PH. Allergy. First published: 07 August 2024
 
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                Prevalence of hypersensitivity reactions in various forms of mastocytosis: A pilot study of 2485 adult patients with mastocytosis collected in the ECNM registryNiedoszytko M, Gorska A, Brockow K, et al. Allergy. First published: 23 April 2024
 
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                High burden of clonal mast cell disorders and hereditary α-tryptasemia in patients who need Hymenoptera venom immunotherapyKorošec P, Sturm GJ, Lyons JJ, et al. Allergy. First published: 13 March 2024
 
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                Global burden of vaccine-associated anaphylaxis and their related vaccines, 1967–2023: A comprehensive analysis of the international pharmacovigilance databaseLee K, Lee H, Kwon R, et al. Allergy. First published: 10 December 2023
 
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                Differential presentation of hypersensitivity reactions to carboplatin and oxaliplatin: Phenotypes, endotypes, and management with desensitizationJimenez-Rodriguez T-W, de las Vecillas L, Labella M, et al. Allergy. First published: 02 November 2023
 
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                Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-Desmethyl Naproxen metabolite but not the acyl glucuronideThomson, P, Fragkas, N, Kafu, LM, et al. Allergy. First published: 29 July 2023
 
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                The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug-reactive T cells in resolved hypersensitivity cases and drug-naïve healthy donorsMifsud, NA, Illing, PT, Ho, R, et al. Allergy. First published: 14 July 2023
 
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                Oral prednisone regulates human skin T cells in delayed-type hypersensitivity reaction elicited by diphencyproneMehta, H., Jack, C., Maari, C., et al. Allergy. First published: 10 May 2023
 
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                Optimal dose of adrenaline auto-injector for children and young people at risk of anaphylaxis: A phase IV randomized controlled crossover studyPatel, N, Isaacs, E, Duca, B, et al. Allergy. First published: 16 February 2023
 
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                Fatal and near-fatal anaphylaxis: the Allergy-Vigilance® Network data (2002-2020)Pouessel, G., Alonzo, S., Divaret-Chauveau, A., Dumond, P., et al. Allergy. First published: 16 January 2023
 
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                Different phenotypes of drug-induced anaphylaxis - data from the European Anaphylaxis RegistryHanschmann, T., Francuzik, W., Dölle-Bierke, S., et al. Allergy. First published: 08 December 2022
 
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                Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective studyCéspedes, J.A., Fernández-Santamaría, R., Ariza, A., et al. Allergy. First published: 07 December 2022
 
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                Intravenous immunoglobulins, cyclosporine and best supportive care in Epidermal Necrolysis: Diverse effects on systemic inflammationSchmidt, V., Lalevée, S., Traidl, S., et al. Allergy. First published: 04 December 2022
 
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                Diagnostic value of a medical algorithm for investigation of perioperative hypersensitivity reactionsSverrild, A., Carruthers, J., Murthee, K.G., et al. Allergy. First published: 22 September 2022
 
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                Resensitisation in suspected penicillin allergyDoña, I., Guidolin, L., Bogas, G., et al. Allergy. First published: 06 September 2022
 
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                Personalized diagnostic approach and indirect quantification of extravasation in human anaphylaxisNuñez-Borque, E., Betancor, D., Carlos, P.-V., et al. Allergy. First published: 16 July 2022
 
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                Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivityWorm, M., Alexiou, A., Bauer, A., et al. Allergy. First published: 20 June 2022
 
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                Synthetic antigenic determinants of clavulanic acid induce dendritic cell maturation and specific T cell proliferation in patients with immediate hypersensitivity reactionsFernandez-Santamaria, R, Bogas, G, Montañez, MI, et al. Allergy. First published: 24 May 2022
 
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                IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cellsStarkl, P., Gaudenzio, N., Marichal, T., et al. Allergy. First published: 11 April 2021
 
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                Platelet-activating factor acetylhydrolase is a biomarker of severe anaphylaxis in childrenUpton, J.E.M., Hoang, J.A., Leon-Ponte, M.,et al. Allergy. First published: 09 April 2022
 
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                Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxisBrockow, K, Mathes, S, Fischer, J, et al. et al. Allergy. First published: 22 November 2021
 
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                The value of the basophil activation test in the evaluation of patients reporting allergic reactions to the BNT162b2 mRNA COVID-19 vaccineLabella, M., Céspedes, J.A., Doña, I., et al. Allergy. First published: 24 October 2021
 
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                Next-generation sequencing and genotype association studies reveal the association of HLA-DRB3*02:02 with delayed hypersensitivity to penicillinsRomano, A., Oussalah, A., Chery, C., et al. Allergy. First published: 23 October 2021
 
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                Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patientsMitamura, Y., Schulz, D., Oro, S., et al. Allergy. First published:22 June 2021
 
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                IgE-cross-blocking antibodies to Fagales following sublingual immunotherapy with recombinant Bet v 1Grilo, J.R., Kitzmüller, C., Aglas, L., et al. Allergy. First published: 16 March 2021
 
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                Nanoarchitectures for efficient IgE cross-linking on effector cells to study amoxicillin allergyTesfaye, A., Rodríguez-Nogales, A., Benedé, S., et al. Allergy. 2021; 76: 3183-3193
 
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                Single-dose prolonged drug provocation test, without previous skin testing, is safe for diagnosing children with mild non-immediate reactions to beta-lactamsPrieto, A., Muñoz, C., Bogas, G., et al. Allergy.2021; 76: 2544-2554
 
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                Childhood vaccination and allergy: A systematic review and meta-analysisNavaratna, S., Estcourt, M.J., Burgess, J., et al. Allergy.2021; 76: 2135-2152
 
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                Dendritic cells inclusion and cell-subset assessment improve flow-cytometry-based proliferation test in non-immediate drug hypersensitivity reactionsFernandez-Santamaria, R., Bogas, G., Palomares, F., et al. Allergy.2021; 76: 2123-2134
 
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                Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestatThomson, PJ, Kafu, L, Meng, X, et al. Allergy. 2021; 76: 1825– 1835
 
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                Digital technology for anaphylaxis management impact on patient behaviour: A randomized clinical trialSala-Cunill, A, Luengo, O, Curran, A, et al. Allergy. 2021; 76: 1507– 1516
 
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                Diagnosing, managing and preventing anaphylaxis: Systematic reviewde Silva, D, Singh, C, Muraro, A, et al. Allergy. 2021; 76: 1493– 1506
 
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                Food-dependent NSAID-induced hypersensitivity (FDNIH) reactions: Unraveling the clinical features and risk factorsSánchez-López, J, Araujo, G, Cardona, V, et al. Allergy. 2021; 76: 1480– 1492
 
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                Diagnostic workup including CD203c-based basophil activation test in immediate hypersensitivity due to metronidazole and ornidazole and evaluation of cross-reactivity in betweenBeyaz, Ş, Akdeniz, N, Yılmaz, A, et al. Allergy. 2021; 76: 842– 852
 
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                IgE-mediated chlorhexidine allergy—Cross-reactivity with other biguanide disinfectantsMueller-Wirth, N, Buenter, A, Jörg, L, et al. Allergy. 2020; 75: 3237– 3247
 
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                Fatal anaphylaxis in Italy: Analysis of cause-of-death national data, 2004-2016Bilò, MB, Corsi, A, Martini, M, Penza, E, Grippo, F, Bignardi, D. llergy. 2020; 75: 2644– 2652
 
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                Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivityAriza, A, Fernández-Santamaría, R, Meng, X, et al. Allergy. 2020; 75: 2562– 2573
 
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                Artificial neural network identifies nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (N-ERD) cohortTyrak, KE, Pajdzik, K, Konduracka, E, et al. Allergy. 2020; 75: 1649– 1658
 
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                Data-driven step doses for drug provocation tests to nonsteroidal anti-inflammatory drugsNohra, D, Molinari, N, Demoly, P, Chiriac, A-M. Allergy. 2020; 75: 1423– 1434
 
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                The role of drug, dose, and the tolerance/intolerance of new drugs in multiple drug hypersensitivity syndromeJörg, L, Yerly, D, Helbling, A, Pichler, W. Allergy. 2020; 75: 1178– 1187
 
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                Secondary prevention measures in anaphylaxis patients: Data from the anaphylaxis registryKraft, M, Knop, MP, Renaudin, J-M, et al. Allergy. 2020; 75: 901– 910
 
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                Interleukin 31 in insect bite hypersensitivity-Alleviating clinical symptoms by active vaccination against itchOlomski, F, Fettelschoss, V, Jonsdottir, S, et al. Allergy. 2020; 75: 862– 871
 
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                Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activationThomson, PJ, Illing, PT, Farrell, J, et al. Allergy. 2020; 75: 636– 647
 
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                Venom immunotherapy in patients with clonal mast cell disorders: IgG4 correlates with protectionJarkvist, J, Salehi, C, Akin, C, Gülen, T. Allergy. 2020; 75: 169– 177
 
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                Large local reactions to Hymenoptera stings: Outcome of re-stings in real lifeilò, MB, Martini, M, Pravettoni, V, et al. Allergy. 2019; 74: 1969– 1976
 
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                Expression of the Tim3-galectin 9 axis is altered in drug-induced maculopapular exanthemaFernandez-Santamaría, R, Palomares, F, Salas, M, et al. Allergy. 2019; 74: 1769– 1779
 
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                Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01Zhao, Q, Alhilali, K, Alzahrani, A, et al. Allergy. 2019; 74: 1533– 1548
 
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                Increased expression of L-plastin in nasal polyp of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory diseaseTakabayashi, T, Tanaka, Y, Susuki, D, et al. Allergy. 2019; 74: 1307- 1316
 
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                Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: An observational studyVitte, J, Amadei, L, Gouitaa, M, et al. Allergy. 2019; 74: 1157– 1165
 
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                The orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axisJin, F, Li, X, Deng, Y, et al. Allergy. 2019; 74: 1145– 1156
 
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                Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticariaDoña, I, Jurado-Escobar, R, Perkins, JR, et al. Allergy. 2019; 74: 1135– 1144
 
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                Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patientsBoehm, T, Reiter, B, Ristl, R, et al. Allergy. 2019; 74: 583– 593
 
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                Active vaccination against interleukin-5 as long-term treatment for insect-bite hypersensitivity in horsesFettelschoss-Gabriel, A, Fettelschoss, V, Olomski, F, et al. Allergy. 2019; 74: 572– 582
 
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                Surfactant protein D alleviates eosinophil-mediated airway inflammation and remodeling in patients with aspirin-exacerbated respiratory diseaseChoi, Y, Lee, D-H, Trinh, HKT, et al. Allergy. 2019; 74: 78– 88
 
