Articles of the Month

Biologicals for severe CRS with nasal polyps

Rhinitis, cold and COVID-19

Allergens and their associated small molecule ligands

Carbohydrate epitopes as targets for IgE

Managing asthma in ICU – potential of biologics

Biosafety of sputum induction during pandemic

BAT – use in clinical trials and clinical practice

Videos

Commonly problematic medical devices and associated contact allergens

N−3 fatty acid supplementation in asthma management: A systematic review and meta-analysis

Potential cancer risk with omalizumab? Analysis of the WHO's VigiBase pharmacovigilance database

Bet v 1 from birch pollen is a hypoallergen with vitamin D3 in the pocket

Articles

Citations: 3335

Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)

Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., Togias, A. et al. Allergy. 2008; 63: 8-160

Citations: 2330

The global burden of asthma: executive summary of the GINA Dissemination Committee Report

Masoli, M., Fabian, D., Holt, S., Beasley, R. Allergy. 2004; 59: 469-478

Citations: 1328

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Zhang, J.-J., Dong, X., Cao, Y.-Y., Yuan, Y.-D., Yan, Y.-Q., Akdis, C., A. and Gao, Y.-D. Allergy. 2020; 75: 1730– 1741

Citations: 1300

A revised nomenclature for allergy - An EAACI position statement from the EAACI nomenclature task force

Johansson, S.G.O., Hourihane, J., Bousquet, J., Bruijnzeel-Koomen, C., Dreborg, S., Haahtela, T. et al. Allergy. 2001; 56: 813-824

Citations: 885

Position Paper - Allergen Standardization and Skin-Tests

Dreborg, S. and Frew, A. Allergy. 1993; 48: 49-54

Citations: 794

Allergenic pollen and pollen allergy in Europe

D’Amato, G., Cecchi, L., Bonini, S., Nunes, C., Annesi-Maesano, I., Behrendt, H. et al. Allergy. 2007; 62: 976-990

Citations: 760

Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE

Humbert, M., Beasley, R., Ayres, J., Slavin, R., Hébert, J., Bousquet, J. et al. Allergy. 2005; 60: 309-316

Citations: 757

The EAACI/GA(2)LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Zuberbier, T., Aberer, W., Asero, R., Bindslev-Jensen, C., Brzoza, Z., Canonica, G., W., et al. Allergy. 2014; 69: 868– 887

Citations: 664

Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study

Jacobsen, L., Niggemann, B., Dreborg, S., Ferdousi, H.A., Halken, .S., Høst, A. et al. Allergy. 2007; 62: 943-948

Citations: 617

EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy

Muraro, A, Werfel, T, Hoffmann-Sommergruber, K, Roberts, G, Beyer, K, Bindslev-Jensen, C, et al. Allergy 2014; 69: 1008– 1025

Citations: 1328

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Zhang, J.-J., Dong, X., Cao, Y.-Y., Yuan, Y.-D., Yan, Y.-Q., Akdis, C., A. and Gao, Y.-D. Allergy. 2020; 75: 1730– 1741

Citations: 245

Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19

Azkur, A.,K., Akdis, M., Azkur, D., Sokolowska, M., van de Veen, W., Brüggen, M.,C. et al. Allergy. 2020; 75: 1564– 1581

Citations: 169

COVID-19 in a designated infectious diseases hospital outside Hubei Province, China

Cai, Q., Huang, D., Ou, P., Yu, H., Zhu, Z., Xia, Z. et al. Allergy. 2020; 75: 1742– 1752

Citations: 119

Eleven faces of coronavirus disease 2019

Dong, X., Cao, Y.-Y., Lu, X.-X., Zhang, Du, H., J.-J., Yan, Y.-Q. et al. Allergy. 2020; 75: 1699– 1709

Citations: 115

Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

Radzikowska, U., Ding, M., Tan, G., Zhakparov, D., Peng, Y., Wawrzyniak, P. et al. Allergy. 2020; 75: 2828– 2844

Citations: 77

Distinct characteristics of COVID-19 patients with initial rRT-PCR-positive and rRT-PCR-negative results for SARS-CoV-2

Zhang, J.-j., Cao, Y.-y., Dong, X., Wang, B.-c., Liao, M.-y., Lin, J. et al. Allergy. 2020; 75: 1809-1812

Citations: 56

Is BCG vaccination affecting the spread and severity of COVID-19?

Ozdemir, C., Kucuksezer, U.,C. and Tamay, Z.,U. Allergy. 2020; 75: 1824-1827

Citations: 55

Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement

Bousquet, J., Akdis, C.,A., Jutel, M., Bachert, C., Klimek, L., Agache, I. et al. Allergy. 2020; 75: 2440-2444

Citations: 52

Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?

Gursel, M. and Gursel, I. Allergy. 2020; 75: 1815-1819

Patients with systemic sclerosis show phenotypic and functional defects in neutrophils

Impellizzieri, D., Egholm, C., Valaperti, A., Distler, O. and Boyman, O. Allergy. First published: 01 September 2021

Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials

Mullol, J., Laidlaw, T.M., Bachert, C., et al. Allergy. First published: 30 August 2021

Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function

Kleuskens, M.T., Haasnoot, M.L., Herpers, B.M., et al. Allergy. First published: 30 August 2021

Real-world evidence of reduced disability costs during the Finnish Allergy Programme 2008-2018

Jantunen, J., Kauppi, P., Linna, M., Mäkelä, M., Pelkonen, A. and Haahtela, T. Allergy. First published: 30 August 2021

Phase 2a Randomized Clinical Trial of Dupilumab (anti-IL-4Rα) for Alopecia Areata Patients

Guttman-Yassky, E., Renert-Yuval, Y., Bares, J., et al. Allergy. First published: 30 August 2021

IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33

Schröder, A., Lunding, L.P., Zissler, U.M., et al. Allergy. First published: 30 August 2021

Group 2 Innate Lymphoid Cells in Patients with Non-Asthmatic Eosinophilic Bronchitis

Zhan, C., Liu, J., Li, B., et al. Allergy. First published: 29 August 2021

In vitro data suggest that Indian variant B.1.617 of SARS-CoV-2 escapes neutralization by both receptor affinity and immune evasion

Augusto, G., Mohsen, M.O., Zinkhan, S., et al. Allergy. First published: 28 August 2021

Neutralization of SARS-CoV-2 requires antibodies against conformational receptor-binding domain epitopes

Gattinger, P., Niespodziana, K., Stiasny, K., et al. Allergy. First published: 28 August 2021

Conjunctival inflammation in dupilumab-treated atopic dermatitis comprises a multicellular infiltrate with elevated T1/T17 cytokines: a case series study

Bakker, D.S., ter Linde, J.J., Amini, M.M., et al. Allergy. First published: 27 August 2021

Automatic screening of self-evaluation apps for urticaria and angioedema shows a high unmet need

Antó, A., Maurer, R., Gimenez-Arnau, A., et al. Allergy. First published: 26 August 2021

Airway remodeling and bronchodilator responses in asthma assessed by endobronchial optical coherence tomography

Su, Z.-Q., Zhou, Z.-Q., Guan, W.-J., et al. Allergy. First published: 26 August 2021

Management of allergic diseases in pregnancy

Pfaller, B., Bendien, S., Ditisheim, A. and Eiwegger, T. Allergy. First published: 24 August 2021

Self-reported nasal hyperreactivity is common in all chronic upper airway inflammatory phenotypes and not related to general well-being

Backaert, W., Steelant, B., Jorissen, M., et al. Allergy. First published: 21 August 2021

Commonly problematic medical devices and associated contact allergens

Dendooven, E., Stappers, S., Lambert, J., Pieters, L., Foubert, K. and Aerts, O. Allergy. First published: 18 August 2021

A new era of atopic eczema research: Advances and highlights

Hülpüsch, C., Weins, A.B., Traidl-Hoffmann, C. and Reiger, M. Allergy. First published: 18 August 2021

Professor Marek L. Kowalski in our memory

Chałubiński, M., Sokołowska, M., Makowska, J., et al. Allergy. First published: 17 August 2021

From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil driven diseases

Pavord, I.D., Bel, E.H., Bourdin, A., et al. Allergy. First published: 17 August 2021

Direct platelet adhesion potentiates group 2 innate lymphoid cell functions

Orimo, K., Tamari, M., Takeda, T., et al. Allergy. First published: 17 August 2021

Antiviral response in vernal keratoconjunctivitis may be protective against COVID-19

Leonardi, A., Rosani, U., Cavarzeran, F., et al. Allergy. First published: 14 August 2021

Detecting immunoglobulins in processed sputa

Cass, S.P., McGrath, J.J., Son, K., et al. Allergy. First published: 14 August 2021

Activation of the mTOR/HIF-1α/VEGF axis promotes M1 macrophage polarization in non-eosCRSwNP

Zhong, B., Du, J., Liu, F., et al. Allergy. First published: 14 August 2021

Bet v 1 from birch pollen is a hypoallergen with vitamin D3 in the pocket

Hufnagl, K., Kromp, L., Bianchini, R., et al. Allergy. First published: 14 August 2021

Sublingual immunotherapy reduces reaction threshold in three patients with wheat-dependent exercise-induced anaphylaxis

Tomsitz, D., Biedermann, T. and Brockow, K. Allergy. First published: 14 August 2021

Advances and highlights in asthma in 2021

Agache, I., Eguiluz-Gracia, I., Cojanu, C., et al. Allergy. First published: 14 August 2021

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Zhang, J.-J., Dong, X., Cao, Y.-Y., Yuan, Y.-D., Yan, Y.-Q., Akdis, C., A. and Gao, Y.-D. Allergy. 2020; 75: 1730– 1741

COVID-19 in a designated infectious diseases hospital outside Hubei Province, China

Cai, Q., Huang, D., Ou, P., Yu, H., Zhu, Z., Xia, Z. et al. Allergy. 2020; 75: 1742– 1752

Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19

Azkur, A.,K., Akdis, M., Azkur, D., Sokolowska, M., van de Veen, W., Brüggen, M.,C. et al. Allergy. 2020; 75: 1564– 1581

Distinct characteristics of COVID-19 patients with initial rRT-PCR-positive and rRT-PCR-negative results for SARS-CoV-2

Zhang, J.-j., Cao, Y.-y., Dong, X., Wang, B.-c., Liao, M.-y., Lin, J. et al. Allergy. 2020; 75: 1809-1812

Eleven faces of coronavirus disease 2019

Dong, X., Cao, Y.-Y., Lu, X.-X., Zhang, Du, H., J.-J., Yan, Y.-Q. et al. Allergy. 2020; 75: 1699– 1709

Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors

Radzikowska, U., Ding, M., Tan, G., Zhakparov, D., Peng, Y., Wawrzyniak, P. et al. Allergy. 2020; 75: 2828– 2844

Is BCG vaccination affecting the spread and severity of COVID-19?

Ozdemir, C., Kucuksezer, U.,C. and Tamay, Z.,U. Allergy. 2020; 75: 1824-1827

Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic?

Gursel, M. and Gursel, I. Allergy. 2020; 75: 1815-1819

See More in the COVID-19 Archive

August 2021 - What is an allergen?

Volume 76 | Issue 8

July 2021 - Allergic inflammation

Volume 76 | Issue 7

May 2021 - Food allergy and anaphylaxis

Volume 76 | Issue 5

April 2021 - Allergic skin diseases

Volume 76 | Issue 4

November 2020 - Patient care, adolescents and young adults

Volume 75 | Issue 11

September 2020 - Climate Change

Volume 75 | Issue 9

Special Issue S109 - Abstracts from the European Academy of Allergy and Clinical Immunology Digital Congress, 06–08 June 2020

Volume 75 | Issue S109

May 2020 - EAACI Biologicals Guidelines

Volume 75 | Issue 5

April 2020 - Innate Immunity and Adjuvants

Volume 75 | Issue 4

March 2020 - Biologicals and Allergen Immunotherapy

Volume 75 | Issue 3

January 2020 - Atopic Dermatitis

Volume 75 | Issue 1

Special Issue: Perspectives in Allergen Immunotherapy: 2019 and Beyond

Volume 74 | Issue S108

December 2019 - Therapy of Allergic Rhinitis

Volume 74 | Issue 12

November 2019 - Allergic Rhinitis

Volume 74 | Issue 11

October 2019 - IgE and Anaphylaxis

Volume 74 | Issue 10

September 2019 - Innate Immunity

Volume 74 | Issue 9

May 2019 - EAACI Guidelines on HDM AIT

Volume 74 | Issue 5

February 2019 - Endotypes and Phenotypes of Asthma

Volume 74 | Issue 2

January 2019 - Thunderstorm Triggered Asthma Attacks

Volume 74 | Issue 1

Basophil activation test: A diagnostic, predictive and monitoring assay for allergen immunotherapy

Alpan, O., Layhadi, J.A., Ulrik Sønder, S., Li, H. and Shamji, M.H. Allergy. 2021; 76: 1321-1324

Anaphylaxis to drugs: Overcoming mast cell unresponsiveness by fake antigens

Pichler, W.,J. Allergy. 2021; 76: 1340– 1349

The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease

Perkins, T.,N, Donnell, M.,L, Oury, T.,D. Allergy. 2021; 76: 1350– 1366

The global burden of illness of peanut allergy: A comprehensive literature review

Lieberman, J.,A, Gupta, R., Knibb, R.,C., Haselkorn, T., Tilles, S., Mack, D., P. and Poussel, G. et al. Allergy. 2021; 76: 1367– 1384

Butyrate as a bioactive human milk protective component against food allergy

Paparo, L, Nocerino, R, Ciaglia, E, et al. Allergy. 2021; 76: 1398– 1415

Predicting food allergy: The value of patient history reinforced

Lyons, SA, Knulst, AC, Burney, PGJ, et al. Allergy. 2021; 76: 1454– 1462

Identification of Pru du 6 as a potential marker allergen for almond allergy

Kabasser, S, Hafner, C, Chinthrajah, S, et al. Allergy. 2021; 76: 1463– 1472

Peanut-induced anaphylaxis in children and adolescents: Data from the European Anaphylaxis Registry

Maris, I., Dölle-Bierke, S., Renaudin, J.-M., Lange, L., Koehli, A., Spindler, T. et al. Allergy. 2021; 76: 1517-1527

Pollen induces reactivation of latent herpesvirus and differentially affects infected and uninfected murine macrophages

Speidel, J.D., Gilles, S., Steer, B., Vafadari, B., Rauer, D., Traidl-Hoffmann, C. and Adler, H. Allergy. 2021; 76: 1539-1542

PIPE-cloned human IgE and IgG4 antibodies: New tools for investigating cow's milk allergy and tolerance

Pranger, C.L., Fazekas-Singer, J., Köhler, V.K., Pali-Schöll, I., Fiocchi, A., Karagiannis, S.N. et al. Allergy. 2021; 76: 1553-1556

Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis

Yuan, S., Vithayathil, M., Kar, S., Carter, P., Mason, A.M., Xie, S.-H., Burgess, S. and Larsson, S.C. Allergy. 2021; 76: 1559-1562

Regional differences in ACE2 expression in the sinonasal mucosa of adult Chinese patients with chronic rhinosinusitis

Werner, P. et al.

Trained immunity and allergy: State of the art and future perspectives

Wang, H., Song, J., Pan, L., Deng, Y.-K., Yao, Y., Wang, Z.-C. et al. Allergy. 2021; 76: 1565-1568

Elucidating the α-Gal syndrome at the molecular allergen level

Kiewiet, M.B.G., Grundström, J., Apostolovic, D., Andersson, M., Borres, M.P., Hamsten, C. et al. Allergy. 2021; 76: 1576-1578

The roadmap for allergology in Europe: The European training requirements for the specialty of allergology

Gerth van Wijk, R., Mülleneisen, N., Demoly, P., Olaguibel, J.M., Popov, T.A., Schmid-Grendelmeier, P. and Tsilochristou, O. Allergy. 2021; 76: 1588-1591

Junior Members Corner

Dear JMs,

The EAACI 2021 Annual Congress will be taking place on 10 - 12 July in a hybrid format, with both a physical part that will be held in Krakow both a digital part to allow anybody to attend safely. You are still on time to register by clicking here to have full live access to EAACI Hybrid Congress 2021 (3 days) and full access On Demand until December 31, 2021.

This is the main event of the Academy, and one of the biggest international dedicated to Allergy and Clinical Immunology. It gathers thousands of delegates from all around the world, and offers simultaneous sessions covering all aspects of our specialty.

Don't miss this opportunity and join us!

As every year the Junior Member Assembly (JMA) has organised some meetings to share knowledge and opportunity among JMs.
Here the Agenda with the highly suggested appointments:

- Monday, 28 June 2021, 15:00-16:00 CET: Open JM Business Meeting.

Invited guest Prof. Cezmi Akdis with the talk “Future direction of epithelial barrier research in the allergy and immunology field”. You can register by clicking here.

- Saturday, 10 July 2021, 14:00-15:30 CET: JMA Scientific Symposium.

Three excellent speeches on the theme "Approaching infants at high risk of allergic disease":
- Dr R. Jiménez-Saiz, “Understanding immunological mechanisms that confer a higher risk of allergy”;
- Dr M. M. Kelleher, “Infants at high risk of food allergy: nutritional and skin barrier repair interventions”;
- Dr I. Eguiluz-Gracia, “Exposome modulation and immunotherapy in infants at higher risk of respiratory allergies”.

- Sunday, 11 July 2021, 14:00-15:30 CET: JMA Educational Session.

Composed of three very current speeches on "Lessons learned from COVID-19 pandemic":
- Dr A. DunnGalvin, “Mental health during the COVID-19 pandemic: how to cope with job stress and build resilience”;
- “Infodemic and the lesson of the COVID-19 pandemic: how to tackle health-related misinformation”;
- Dr B. Moya, “COVID-19 vaccination: Separating facts from fiction for your patients”.

Save the dates!

Looking forward to meeting you all at the 2021 EAACI Annual Hybrid Congress!