Original Articles: Rhinitis, Sinusitis, and Upper Airway Disease
Rhinitis, sinusitis, and other upper airway diseases are common conditions affecting the nasal passages and sinuses, leading to symptoms like congestion, runny nose, sneezing, and facial pain. Rhinitis can be allergic, triggered by allergens such as pollen and dust mites, or non-allergic, caused by factors like infections or irritants. Sinusitis, an inflammation of the sinuses, often follows a cold or respiratory infection and can become chronic, lasting for months.
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90 Articles |
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Dupilumab Treatment Is Associated With Clinical Improvement and a Shift Toward a Health-Associated Nasal Passage Microbiota in Diffuse Type 2 Chronic Rhinosinusitis
Ryser, F.S., Demeter, T., Pijuan, J.B., et al. Allergy. First published: 02 June 2025
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Two-Year Data of Tapered Dupilumab Shows High Effectiveness in CRSwNP With NSAID-Exacerbated Respiratory Disease
Elzinga, H.B.E., Otten, J.J., Cornet, M.E., et al. Allergy. First published:16 May 2025
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Amphiregulin Mediates Epithelial Cell–Eosinophil Interactions and Amplifies Inflammation in Chronic Rhinosinusitis With Nasal Polyps
Zhao, L., Zhang, S., Zhang, Y., et al. Allergy. First published: 02 May 2025
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Clinical Benefits of a Randomized Allergy App Intervention in Grass Pollen Sufferers: A Controlled Trial
Holzmann, C., Karg, J., Reiger, M., et al. Allergy. First published:17 April 2025
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Comparative Evaluation of an Allergen Exposure Chamber and Nasal Allergen Challenge Versus In-Field Symptom Assessment in Patients With Allergic Rhinitis Triggered by Timothy Grass Pollen
Zemelka-Wiacek, M., Kosowska, A., Pfaar, O., et al. Allergy. First published: 09 March 2025
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Hypoxia-reduced YAP phosphorylation enhances expression of Mucin5AC in nasal epithelial cells of chronic rhinosinusitis with nasal polyps
Zhong B, Liu J, Ong HH, et al. Allergy. First published: 13 November 2024
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Investigation of the diagnostic accuracy of basophil activation test for allergic phenotypes of rhinitis
Testera-Montes A, Ariza A, Sola-Martinez RA, et al. Allergy. First published: 05 November 2024
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NRP1 antagonism as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis
Khalmuratova R, Ryu J-S, Hwang JH, et al.Allergy. First published: 21 August 2024
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Characterising the allergic fungal rhinosinusitis microenvironment using full-length 16S rRNA gene amplicon sequencing and fungal ITS sequencing
Connell JT, Bouras G, Yeo K, et al. Allergy. First published: 24 July 2024
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Forecasting daily total pollen concentrations on a global scale
Makra L, Coviello L, Gobbi A, et al.Allergy. First published: 12 July 2024
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Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades
Perret JL, Idrose NS, Walters EH, et al.Allergy. First published: 10 July 2024
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Network analysis reveals age- and virus-specific circuits in nasal epithelial cells of extremely premature infants
Wisgrill L, Martens A, Kasbauer R, et al. Allergy. First published: 19 June 2024
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Multi-omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis
Irizar H, Chun Y, Hsu H-H, et al.Allergy. First published: 26 May 2024
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AM-301, a barrier-forming nasal spray, versus saline spray in seasonal allergic rhinitis: A randomized clinical trial
Becker S, Deshmukh S, De Looze F, et al. Allergy. First published: 06 April 2024
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Nasal allergen-neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis
Eguiluz-Gracia I, Parkin RV, Layhadi JA, et al. Allergy. First published: 14 March 2024
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Immune signatures predict response to house dust mite subcutaneous immunotherapy in patients with allergic rhinitis
Wang N, Song J, Sun S-R, et al. Allergy. First published: 25 February 2024
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Heterogeneity of sensitization profiles and clinical phenotypes among patients with seasonal allergic rhinitis in Southern European countries—The @IT.2020 multicenter study
Dramburg S, Grittner U, Potapova E, et al. Allergy. First published: 05 February 2024
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Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy
Wipperman MF, Gayvert KM, Atanasio A, et al. Allergy. First published: 27 January 2024
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Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis
Lubner RJ, Rubel K, Chandra RK, et al. Allergy. First published: 05 January 2024
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Natural course of pollen-induced allergic rhinitis from childhood to adulthood: A 20-year follow up
Lindqvist M, Leth-Møller KB, Linneberg A, et al. Allergy. First published: 02 November 2023
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Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis
Soliai, MM, Kato, A, Naughton, KA, et al. Allergy. First published: 12 August 2023
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Dupilumab-induced eosinophilia in patients with diffuse type 2 chronic rhinosinusitis
Ryser, FS, Yalamanoglu, A, Valaperti, A, et al. Allergy. First published: 07 August 2023
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Two-year results of tapered dupilumab for CRSwNP demonstrates enduring efficacy established in the first 6 months
van der Lans, RJL, Otten, JJ, Adriaensen, GFJPM, et al. Allergy. First published: 02 July 2023
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Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): a multicentric observational phase 4 real-life study (DUPIREAL)
De Corso, E., Pasquini, E., Trimarchi, M., et al. Allergy. First published: 18 May 2023
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Sinus inflammation and chronic rhinosinusitis are associated with a diagnosis of new onset asthma in the following year
Schwartz, BS, Pollak, JS, Bandeen-Roche, K, et al. Allergy. First published: 17 May 2023
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IL-4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation
Cho, H-J, Chung, YW, Moon, S, et al. Allergy. First published: 08 March 2023
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Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study
Sousa-Pinto, B, Schünemann, HJ, Sá-Sousa, A, et al. Allergy. First published: 03 November 2022
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Predicting dupilumab treatment outcome in patients with primary diffuse type 2 chronic rhinosinusitis
Soyka, M.B., Ryser, F.S., Brühlmann, C., et al. Allergy. First published: 26 September 2022
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Validated allergen exposure chamber is plausible tool for assessment of house dust mite-triggered allergic rhinitis
Zemelka-Wiacek, M., Kosowska, A., Winiarska, E., et al. Allergy. First published: 18 August 2022
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Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): in-depth sinus surgery analysis
Fokkens, W.J., Mullol, J., Kennedy, D., et al. Allergy. First published: 13 July 2022
Sequential class switch recombination to IgE and allergen-induced accumulation of IgE+ plasmablasts occur in the nasal mucosa of local allergic rhinitis patients
Testera-Montes, A., Palomares, F., Jurado-Escobar, R., et al. Allergy. First published: 27 March 2022
Transcriptomics of rhinovirus persistence reveals sustained expression of RIG-I and interferon-stimulated genes in nasal epithelial cells in vitro
Ong, H.H., Andiappan, A.K., Duan, K., et al. Allergy. First published: 10 March 2022
Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air® real-world data
Sousa-Pinto, B., Sá-Sousa, A., Vieira, R.J., et al. Allergy. First published: 08 March 2022
The prevalence of non-allergic rhinitis phenotypes in the general population: a cross-sectional study
Avdeeva, K.S., Fokkens, W.J., Segboer, C.L. and Reitsma, S. Allergy. First published: 17 January 2022
Dupilumab improves health-related quality of life in severe chronic rhinosinusitis with nasal polyps
Lee, S.E., Hopkins, C., Mullol, J. et al. Allergy. First published: 16 January 2022
Development and validation of combined symptom-medication scores for allergic rhinitis
Sousa-Pinto, B., Filipe Azevedo, L., Jutel, M., et al. Allergy. First published: 21 December 2021
Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota
Zhao, Y, Chen, J, Hao, Y, et al. Allergy. First published: 04 November 2021
miR-146a enhances regulatory T-cell differentiation and function in allergic rhinitis by targeting STAT5b
Zhang, Y, Yang, Y, Guo, J, et al. Allergy. First published: 30 October 2021
CD103 integrin identifies a high IL-10-producing FoxP3+ regulatory T cell population suppressing allergic airway inflammation
Tagkareli, S., Salagianni, M., Galani, I.-E., et al. Allergy. First published: 17 October 2021
Large-scale provocation studies identify maladaptive responses to ubiquitous aeroallergens as a correlate of severe allergic rhinoconjunctivitis and asthma
Smith, A.M., Ramirez, R.M., Harper, N., et al. Allergy. First published: 04 October 2021
A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2
Mohsen, MO, Balke, I, Zinkhan, S, et al. Allergy. First published: 08 September 2021
Efficacy and safety of dupilumab in patients with uncontrolled severe CRSwNP and a clinical diagnosis of NSAID-ERD: Results from two randomized placebo-controlled phase 3 trials
Mullol, J., Laidlaw, T.M., Bachert, C., et al. Allergy. First published: 30 August 2021
Association between mucosal barrier disruption by pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis
Tuli, J.F., Ramezanpour, M., Cooksley, C., Psaltis, A.J., Wormald, P.-J. and Vreugde, S. Allergy. First published: 25 May 2021
The maternal diet index in pregnancy is associated with offspring allergic diseases: the Healthy Start study
Venter, C, Palumbo, MP, Glueck, DH, et al.Allergy. First published: 22 May 2021
Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2LEN consensus
Hagemann, J., Onorato, G.L., Jutel, M., et al. Allergy. First published: 17 March 2021
Dupilumab efficacy in chronic rhinosinusitis with nasal polyps from SINUS-52 is unaffected by eosinophilic status
Fujieda, S, Matsune, S, Takeno, S, et al.Allergy. First published: 16 May 2021
Overcoming bacteriophage insensitivity in staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations
Liu, S., Zhao, Y., Hayes, A., Allergy. 2021; 76: 3446-3458
Heterogeneity of pollen food allergy syndrome in seven Southern European countries: the @IT.2020 multicenter study
Lipp, T., Acar Şahin, A., Aggelidis, X., et al. Allergy. 2021; 76: : 3041-3052
Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort
Sigurdardottir, ST, Jonasson, K, Clausen, M, et al. Allergy. 2021; 76: 2855– 2865
Effect of intranasal corticosteroid treatment on allergen-induced changes in group 2 innate lymphoid cells in allergic rhinitis with mild asthma
Xie, Y., Ju, X., Beaudin, S., et al. Allergy. 2021; 76: 2797-2808
Tear N-glycomics in vernal and atopic keratoconjunctivitis
Messina, A., Palmigiano, A., Tosto, C., et al. Allergy.2021; 76: 2500-2509
Ragweed plants grown under elevated CO2 levels produce pollen which elicit stronger allergic lung inflammation
Rauer, D, Gilles, S, Wimmer, M, et al. Allergy. 2021; 76: 1718-1730
A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog
Kagoya, R, Kondo, K, Kishimoto-Urata, M, et al. Allergy. 2021; 76: 1432– 1442
Stromal cells and B cells orchestrate ectopic lymphoid tissue formation in nasal polyps
Wang, Z-Z, Song, J, Wang, H, et al. Allergy. 2021; 76: 1416– 1431
Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps
Wang, M, Bu, X, Fang, G, et al. Allergy. 2021; 76: 789– 803
Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps
Shi, L-L, Ma, J, Deng, Y-K, et al. Allergy. 2021; 76: 497– 509
A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents
Lemonnier, N, Melén, E, Jiang, Y, et al. Allergy. 2020; 75: 3248– 3260
Real-life assessment of chronic rhinosinusitis patients using mobile technology: The mySinusitisCoach project by EUFOREA
Seys, SF, De Bont, S, Fokkens, WJ, et al. Allergy. 2020; 75: 2867– 2878
CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis
Yao, Y, Wang, N, Chen, C-L, et al. Allergy. 2020; 75: 2599– 2612
Tnfaip3 expression in pulmonary conventional type 1 Langerin-expressing dendritic cells regulates T helper 2-mediated airway inflammation in mice
Vroman, H, van Uden, D, Bergen, IM, et al. Allergy. 2020; 75: 2587– 2598
The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology
Paramasivan, S, Bassiouni, A, Shiffer, A, et al. Allergy. 2020; 75: 2037– 2049
Artemisia annua-sublingual immunotherapy for seasonal allergic rhinitis: A randomized controlled trial
Lou, H, Huang, Y, Ouyang, Y, et al. Allergy. 2020; 75: 2026– 2036
Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: Follow-up of a randomized trial
Roßberg, S, Keller, T, Icke, K, et al. Allergy. 2020; 75: 2020– 2025
Eleven faces of coronavirus disease 2019
Dong, X, Cao, Y-Y, Lu, X-X, et al. Allergy. 2020; 75: 1699– 1709
Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis
Eguiluz-Gracia, I, Fernandez-Santamaria, R, Testera-Montes, A, et al. Allergy. 2020; 75: 1689– 1698
Correlation between work impairment, scores of rhinitis severity and asthma using the MASK-air(®) App
Bédard, A, Antó, JM, Fonseca, JA, et al. Allergy. 2020; 75: 1672– 1688
"Whole" vs. "fragmented" approach to EAACI pollen season definitions: A multicenter study in six Southern European cities
Hoffmann, TM, Acar Şahin, A, Aggelidis, X, et al. Allergy. 2020; 75: 1659– 1671
Macrophage-derived progranulin promotes allergen-induced airway inflammation
Choi, J-P, Park, SY, Moon, K-A, et al. Allergy. 2020; 75: 1133– 1145
Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation
Kortekaas Krohn, I, Seys, SF, Lund, G, et al. Allergy. 2020; 75: 1155– 1164
Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample
Hirsch, AG, Nordberg, C, Bandeen-Roche, K, et al. Allergy. 2020; 75: 911– 920
Profilin is a marker of severity in allergic respiratory diseases
Ruiz-Hornillos, J, López-Matas, MA, Berges Jimeno, P, et al. Allergy. 2020; 75: 853– 861
Allergic rhinitis and allergic sensitisation are still increasing among Danish adults
Leth-Møller, KB, Skaaby, T, Linneberg, A. Allergy. 2020; 75: 660– 668
Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice
Roula, D, Theiler, A, Luschnig, P, et al. Allergy. 2020; 75: 392– 402
Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinitis
Tojima, I, Matsumoto, K, Kikuoka, H, et al. Allergy. 2019; 74: 2417– 2426
Determination of the minimally important difference in a nasal symptom score in house dust mite allergy
Devillier, P, Brüning, H, Bergmann, K-C. Allergy. 2019; 74: 2191– 2198
Pollen exposure at birth and adolescent lung function, and modification by residential greenness
Lambert, KA, Lodge, C, Lowe, AJ, et al. Allergy. 2019; 74: 1977– 1984
Google trends and pollen concentrations in allergy and airway diseases in France
Bousquet, J, Onorato, GL, Oliver, G, et al. Allergy. 2019; 74: 1910– 1919
Bronchial asthma triggered by house dust mites in patients with local allergic rhinitis
Campo, P, Eguiluz-Gracia, I, Plaza-Serón, MC, et al. Allergy. 2019; 74: 1502– 1510
Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: A retrospective database study in France
Devillier, P, Molimard, M, Ansolabehere, X, et al. Allergy. 2019; 74: 1317– 1326
Increased expression of L-plastin in nasal polyp of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease
Takabayashi, T, Tanaka, Y, Susuki, D, et al. Allergy. 2019; 74: 1307- 1316
Mobile health tools for the management of chronic respiratory diseases
Sleurs, K, Seys, SF, Bousquet, J, et al. Allergy. 2019; 74: 1292- 1306
Safety and reproducibility of nasal allergen challenge
Eguiluz-Gracia, I, Testera-Montes, A, González, M, et al. Allergy. 2019; 74: 1125– 1134
Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis
Miyata, J, Fukunaga, K, Kawashima, Y, et al. Allergy. 2019; 74: 1113– 1124
Dupilumab reduces local type 2 pro-inflammatory biomarkers in chronic rhinosinusitis with nasal polyposis
Jonstam, K, Swanson, BN, Mannent, LP, et al. Allergy. 2019; 74: 743– 752
The hippo pathway effector Yes-associated protein promotes epithelial proliferation and remodeling in chronic rhinosinusitis with nasal polyps
Deng, H, Sun, Y, Wang, W, et al. Allergy. 2019; 74: 731– 742
Endotypes of chronic rhinitis: A cluster analysis study
Meng, Y, Lou, H, Wang, Y, et al. Allergy. 2019; 74: 720– 730
Disentangling the heterogeneity of allergic respiratory diseases by latent class analysis reveals novel phenotypes
Amaral, R, Bousquet, J, Pereira, AM, et al. Allergy. 2019; 74: 698– 708
Type 2/Th2-driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model
Rouyar, A, Classe, M, Gorski, R, et al. Allergy. 2019; 74: 549– 559
Asthma diagnosis using integrated analysis of eosinophil microRNAs
Rodrigo-Muñoz, JM, Cañas, JA, Sastre, B, et al. Allergy. 2019; 74: 507– 517
Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis
Mortz, CG, Andersen, KE, Poulsen, LK, Kjaer, HF, Broesby-Olsen, S, Bindslev-Jensen, C. Allergy. 2019; 74: 308– 317
Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps
Zhang, Y, Derycke, L, Holtappels, G, et al. Allergy. 2019; 74: 131– 140