Barriers and Microbiome
"Tissue barriers, such as the skin, gut, and respiratory tract, play a crucial role in protecting the body from harmful pathogens and maintaining overall health. The microbiome, consisting of trillions of microorganisms living on and inside the body, interacts closely with these barriers, influencing various aspects of human physiology, immunity, and metabolism.
Understanding the complex interplay between barriers and the microbiome is essential for developing strategies to promote health and prevent disease. Ongoing research aims to elucidate the mechanisms underlying this relationship and explore innovative approaches, such as probiotics, prebiotics, and microbiome-targeted therapies, to restore microbial balance and enhance barrier function. Efforts to address these issues are crucial for improving global health outcomes and reducing the burden of chronic diseases.
Recent research has highlighted the intricate relationship between epithelial barriers and the microbiome, shedding light on how disruptions in this relationship can contribute to the development of various diseases, including allergies, autoimmune disorders, and metabolic conditions. Factors such as diet, antibiotics, and environmental exposures can significantly impact the composition and function of the microbiome, affecting barrier function and overall health.
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114 Articles |
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Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial
Aktas, O.N., Mateja, A., Li, M., et al. Allergy. First published: 13 January 2025
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Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs
Ardicli S, Ardicli O, Yazici D, et al. Allergy. First published:17 October 2024
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The epithelial barrier theory and its associated diseases
Sun N, Ogulur I, Mitamura Y, et al. Allergy. First published: 07 October 2024
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Nutritional and environmental exposures in athletes: Implications on the epithelial barrier function
Angelina, A., Pérez-Diego, M. and Palomares, O. Allergy. First published: 19 August 2024
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Transcriptomic profiles of well-differentiated airway epithelial cells in response to environmental triggers of asthma exacerbation
Marrocco, A., Mitchel, J.A., Parker, M., et al. Allergy. First published: 07 August 2024
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Comprehensive analysis of resilience of human airway epithelial barrier against short-term PM2.5 inorganic dust exposure using in vitro microfluidic chip and ex vivo human airway models
Goksel O, Sipahi MI, Yanasik S, et al. Allergy. First published: 13 June 2024
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Pyroptosis, gasdermins and allergic diseases
Panganiban RA, Nadeau KC, Lu Q. Allergy. First published: 14 July 2024
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Skin tape-strips in old order Mennonite toddlers reveal upregulated barrier markers and low T-helper inflammatory tone
Rothenberg-Lausell, C., David, E., Del Duca, et al. Allergy. First published: 30 May 2024
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Epithelial barrier theory in the context of nutrition and environmental exposure in athletes
Kistler W, Villiger M, Villiger B, et al. Allergy. First published: 09 March 2024
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Neonatal skin dysbiosis to infantile atopic dermatitis: Mitigating effects of skin care
R. Aoyama, S. Nakagawa, Y. Ichikawa, et al. Allergy. First published: 09 March 2024
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Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases
R. Berni Canani, M. Caminati, L. Carucci and I. Eguiluz-Gracia. Allergy. First published: 04 March 2024
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Association between gut microbiota development and allergy in infants born during pandemic-related social distancing restrictions
K. Korpela, S. Hurley, S. A. Ford, et al. Allergy. First published: 29 February 2024
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Epidermal barrier impairment predisposes for excessive growth of the allergy-associated yeast Malassezia on murine skin
F. Ruchti, P. Zwicky, B. Becher, S. Dubrac and S. LeibundGut-Landmann.Allergy. First published: 22 February 2024
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Transcriptomic evaluation of skin tape-strips in children with allergic asthma uncovers epidermal barrier dysfunction and asthma-associated biomarkers abnormalities
E. Del Duca, D. Dahabreh, M. Kim, et al. Allergy. First published:20 February 2024
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Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions
Z. Q. Huang, J. Liu, L. Y. Sun, et al. Allergy. First published: 19 February 2024
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Airway epithelial cell cilia transcriptomic dysregulation is associated with the inflammatory phenotype in asthma
M. A. Devilliers, A. Brisebarre, L. M. G. Petit, et al. Allergy. First published: 19 February 2024
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Infant lung function and early skin barrier impairment in the development of asthma at age 3 years
M. Fardig, A. Hoyer, C. Almqvist, K. E. S. et al. Allergy. First published:18 January 2024
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Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80
Ogulur I, Yazici D, Pat Y, et al. Allergy. First published: 02 August 2023
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Helminths' therapeutic potential to treat intestinal barrier dysfunction
Mules TC, Inns S, Le Gros G. Allergy. First published: 14 July 2023
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Detection of gut and mucosal peptides through TOMAHAQ in healthy individuals
Parsons, E.S., Liu, F., Kaushik, A., et al. Allergy. First published: 05 March 2023
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Protease allergens as initiators–regulators of allergic inflammation
Soh WT, Zhang J, Hollenberg MD, et al. Allergy. First published: 16 February 2023
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CU06-1004 alleviates vascular hyperpermeability in a murine model of hereditary angioedema by protecting the endothelium
Lee S, Kim Y, Kim Y-S, et al. Allergy. First published: 14 February 2023
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Detergent-induced eosinophilic inflammation in the esophagus: A key evidence for the epithelial barrier theory
Yazici, D., Pat, Y., Mitamura, Y., Akdis, C.A. and Ogulur, I. Allergy. First published: 16 January 2023
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Household laundry detergents disrupt barrier integrity and induce inflammation in mouse and human skin
A. O. Rinaldi, M. Li, E. Barletta, P. D'Avino, D. Yazici, Y. Pat, et al. Allergy. First published: 27 September 2023
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Electrical impedance spectroscopy detects skin barrier dysfunction in childhood atopic dermatitis
Sasaki M, Sundberg M, Frei R, et al. Allergy. First published: 27 September 2023
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Early-life fecal metabolomics of food allergy
Lee-Sarwar, K.A., Chen, Y.-C., Lasky-Su, J., et al. Allergy. First published: 30 November 2022
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The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes
Lee-Sarwar KA, Chen Y-C, Chen YY, et al. Allergy. First published: 15 September 2022
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Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis
Avlas, S, Shani, G, Rhone, N, et al. Allergy. First published: 07 September 2022
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Functional role of ST6GALNAC1-mediated sialylation of mucins in preserving intestinal barrier integrity and ameliorating inflammation
Sánchez-Martínez E, Garrido-Romero M, Moreno FJ. Allergy. First published: 01 September 2022
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The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy
Sasaki, M., Schwab, C., Ramirez Garcia, A., et al. Allergy. First published: 02 August 2022
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Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus
Doyle AD, Masuda MY, Pyon GC, et al. Allergy. First published: 28 July 2022