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Barriers and Microbiome

"Tissue barriers, such as the skin, gut, and respiratory tract, play a crucial role in protecting the body from harmful pathogens and maintaining overall health. The microbiome, consisting of trillions of microorganisms living on and inside the body, interacts closely with these barriers, influencing various aspects of human physiology, immunity, and metabolism. Understanding the complex interplay between barriers and the microbiome is essential for developing strategies to promote health and prevent disease. Ongoing research aims to elucidate the mechanisms underlying this relationship and explore innovative approaches, such as probiotics, prebiotics, and microbiome-targeted therapies, to restore microbial balance and enhance barrier function. Efforts to address these issues are crucial for improving global health outcomes and reducing the burden of chronic diseases.

Recent research has highlighted the intricate relationship between epithelial barriers and the microbiome, shedding light on how disruptions in this relationship can contribute to the development of various diseases, including allergies, autoimmune disorders, and metabolic conditions. Factors such as diet, antibiotics, and environmental exposures can significantly impact the composition and function of the microbiome, affecting barrier function and overall health.


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114 Articles

  • Epithelial and sensory mechanisms of nasal hyperreactivity
    Velasco, E., Delicado-Miralles, M., Hellings, P.W., et al. Allergy. First published: 17 February 2022

  • House dust mite sensitization and exposure affects bronchial epithelial anti-microbial response to viral stimuli in patients with asthma
    Cerps, S., Sverrild, A., Ramu, S., et al. Allergy. First published: 03 February 2022

  • A step closer to understanding the relationship between host and gut microbiota metabolism
    Barker-Tejeda, T., Zubeldia-Varela, E. and Obeso, D. Allergy. First published: 04 February 2022

  • Is epithelial barrier hypothesis the key to understanding the higher incidence and excess mortality during COVID-19 pandemic? - The case of Northern Italy
    Fiorito, S., Soligo, M., Gao, Y., Ogulur, I., Akdis, C.A. and Bonini, S. Allergy. First published: 31 January 2022

  • MUC1 deficiency induces the nasal epithelial barrier dysfunction via RBFOX3 shortage augment ubiquitin-proteasomal degradation in allergic rhinitis pathogenesis
    Zhang C, Wang Y, Liao W, et al. Allergy. First published: 29 January 2022

  • Epigenetic regulation of epithelial dectin-1 through an IL-33-STAT3 axis in allergic disease
    Yong, H.M., Gour, N., Sharma, D., et al. Allergy. 2022; 77: 207– 217

  • The bile acid-activated retinoic acid response in dendritic cells is involved in food allergen sensitization
    CWu, R, Yuan, X, Li, X, et al. Allergy. 2022; 77: 483– 498

  • Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota
    Zhao Y, Chen J, Hao Y, et al. Allergy. 2022; 77: 540-549

  • Immune-epithelial barrier interactions mediate intestinal adaptation to diverse diets
    Avino, G., Riggioni, C. and Comberiati, P. Allergy. First published: 12 November 2021

  • Epithelial barrier dysfunction in ocular Allergy
    Singh, N, Diebold, Y, Sahu, SK, Leonardi, A. Allergy. First published: 10 November 2021

  • Impaired skin barrier and allergic sensitization in early infancy
    Wärnberg Gerdin, S, Lie, A, Asarnoj, A, et al. Allergy. First published: 05 November 2021

  • Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota
    Zhao, Y, Chen, J, Hao, Y, et al. Allergy. First published: 04 November 2021

  • Bacteriotherapy with human skin commensals in atopic dermatitis
    Castillo-González, R., Fernández-Delgado, I. and Comberiati, P. Allergy. First published: 28 October 2021

  • Increased circulating CRTH2(+)Tregs are associated with asthma control and exacerbation
    Chantveerawong, T., Sangkangjanavanich, S., Chiewchalermsri, C., et al. Allergy. First published: 22 October 2021

  • Specific T cells targeting Staphylococcus aureus Fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients
    Farag, A.K., Roesner, L.M., Wieschowski, S., et al. Allergy. First published: 03 October 2021

  • Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function
    Kleuskens, MTA, Haasnoot, ML, Herpers, BM, et al. Allergy. First published: 30 August 2021

  • Early intervention and prevention of allergic diseases
    Brough, H., Lanser, B.J., Sindher, S.B., et al. Allergy. First published: 13 July 2021

  • Association between mucosal barrier disruption by pseudomonas aeruginosa exoproteins and asthma in patients with chronic rhinosinusitis
    Tuli, J.F., Ramezanpour, M., Cooksley, C., Psaltis, A.J., Wormald, P.-J. and Vreugde, S. Allergy. First published: 25 May 2021

  • ACE2 downregulation in olfactory mucosa: eosinophilic rhinosinusitis as COVID-19 protective factor?
    Marin, C., Tubita, V., Langdon, C. et al. Allergy. First published: 13 May 2021

  • The epithelial barrier hypothesis: a 20-year journey
    Pat, Y. and Ogulur, I. Allergy. First published: 12 May 2021

  • Immunological resilience and biodiversity for prevention of allergic diseases and asthma
    Haahtela, T., Alenius, H., Lehtimäki, J., et al. Allergy. First published: 06 May 2021

  • Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis
    Rinaldi, A.O., Korsfeldt, A., Ward, S. et al. Allergy. First published: 08 April 2021

  • Infant gut microbiome is enriched with Bifidobacterium longum ssp. infantis in Old Order Mennonites with traditional farming lifestyle
    Seppo, A.E., Bu, K., Jumabaeva, M., Thakar, J., et al. Allergy. 2021; 76: 3489-3503

  • A new era of atopic eczema research: Advances and highlights
    Hülpüsch, C, Weins, AB, Traidl-Hoffmann, C, Reiger, M. Allergy. 2021; 76: 3408-3421

  • Dangerous liaisons: Bacteria, antimicrobial therapies, and allergic diseases
    Tramper-Stranders, G, Ambrożej, D, Arcolaci, A, et al. Allergy. 2021; 76: 3276– 3291

  • Genetic variants in the TLR-related pathway and smoking exposure alter the upper airway microbiota in adult asthmatic patients
    Losol, P., Kim, S.-H., Ahn, S., et al.Allergy. 2021; 76: 3217-3220

  • Metagenomic analysis of the conjunctival bacterial and fungal microbiome in vernal keratoconjunctivitis
    Leonardi, A., Modugno, R.L., Cavarzeran, F. and Rosani, U. Allergy. 2021; 76: 3215-3217

  • Direct assessment of individual skin barrier components by electrical impedance spectroscopy
    Mannweiler, R., Bergmann, S., Vidal-y-Sy, S., Brandner, J.M. and Günzel, D. Allergy. 2021; 76: 3094-3106

  • An integrated scalp and blood biomarker approach suggeststhe systemic nature of alopecia areata
    Glickman, J.W., Dubin, C., Dahabreh, D., et al. Allergy. 2021; 76: 3053-3065

  • Eczema herpeticum in atopic dermatitis
    Traidl, S., Roesner, L., Zeitvogel, J. and Werfel, T. Allergy. 2021; 76: 3017-3027

  • Time matters: the circadian rhythm in intestinal homeostasis and food allergy
    Koidl, L., Rohrhofer, J. and Untersmayr, E. Allergy. 2021; 76: 2931-2933

  • Epithelial expression and role of secreted STC1 on asthma airway hyperresponsiveness through calcium channel modulation
    Xu, J., Meng, Y., Jia, M., et al. Allergy.2021; 76: 2475-2487

  • Breastfeeding promotes early neonatal regulatory T-cell expansion and immune tolerance of non-inherited maternal antigens
    Wood, H., Acharjee, A., Pearce, H., et al. Allergy.2021; 76: 2447-2460

  • Immunonutrition: The importance of a new European Academy of Allergy and Clinical Immunology working group addressing a significant burden and unmet need
    Venter, C. and O’Mahony, L. Allergy.2021; 76: 2303-2305

  • Decreased butyric acid-producing bacteria in gut microbiota of children with egg allergy
    Yamagishi, M., Akagawa, S., Akagawa, Y., et al.Allergy.2021; 76: 2279-2282

  • Role of salivary microbiome in IL-10 production and efficacy of sublingual immunotherapy
    Oka, A., Kidoguchi, M., Kariya, S., et al.Allergy.2021; 76: 2617-2620

  • Pros and cons: Is faecal microbiota transplantation a safe and efficient treatment option for gut dysbiosis?
    Marrs, T. and Walter, J. Allergy.2021; 76: 2312-2317

  • Uncovering the immunological properties of isolated lymphoid follicles
    Obeso, D., Zubeldia-Varela, E. and Villaseñor, A. Allergy.2021; 76: 2306-2308

  • MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells
    Igarashi, A., Matsumoto, K. and Matsuda, A.Allergy.2021; 76: 2264-2267

  • IL-13 signature in severe adult asthmatics with airway neutrophilia: a new endotype to treat!
    Mukherjee, M. and Agache, I. Allergy.2021; 76: 1964-1966

  • Inhibition of CpG methylation improves the barrier integrity of bronchial epithelial cells in asthma
    Wawrzyniak, P., Krawczyk, K., Acharya, S., et al. Allergy.2021; 76: 1864-1868.

  • Effect of topical swallowed steroids on the bacterial and fungal esophageal microbiota in eosinophilic esophagitis
    Benitez, A.J., Tanes, C., Mattei, L., et al.Allergy.2021; 76: 1549-1552

  • A murine model of eosinophilic chronic rhinosinusitis using the topical application of a vitamin D3 analog
    Kagoya, R, Kondo, K, Kishimoto-Urata, M, et al. Allergy. 2021; 76: 1432– 1442

  • Butyrate as a bioactive human milk protective component against food allergy
    Paparo, L, Nocerino, R, Ciaglia, E, et al. Allergy. 2021; 76: 1398– 1415

  • Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites
    Ottman, N, Barrientos-Somarribas, M, Fyhrquist, N, et al. Allergy. 2021; 76: 1173– 1187

  • Interplay between skin microbiota and immunity in atopic individuals
    Riskumäki, M., Tessas, I., Ottman, N., et al.Allergy.2021; 76: 1280-1284

  • Dupilumab reduces inflammation and restores the skin barrier in patients with atopic dermatitis
    Rohner, M.H., Thormann, K., Cazzaniga, S., et al. Allergy.2021; 76: 1268-1270

  • Increased diversity of gut microbiota during active oral immunotherapy in peanut-allergic adults
    He, Z., Vadali, V.G., Szabady, R.L., et al.Allergy.2021; 76: 927-930

  • Angiotensin-converting enzyme II expression and its implication in the association between COVID-19 and allergic rhinitis
    Wang, H., Song, J., Yao, Y., et al. Allergy. 2021; 76: 906-910

  • Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
    Bousquet, J, Anto, JM, Czarlewski, W, et al. Allergy. 2021; 76: 735– 750

  • Impact of diet and the bacterial microbiome on the mucous barrier and immune disorders
    Alemao, CA, Budden, KF, Gomez, HM, et al. Allergy. 2021; 76: 714– 734

  • Role of yes-associated protein in interleukin-13 induced nasal remodeling of chronic rhinosinusitis with nasal polyps
    Yuan, T., Zheng, R., Liu, J., et al. Allergy.2021; 76: 600-604

  • Characterization of conjunctival microbiome dysbiosis associated with allergic conjunctivitis
    Liang, Q., Li, J., Zhang, S., et al. Allergy.2021; 76: 596-600

  • Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps
    Shi, L-L, Ma, J, Deng, Y-K, et al. Allergy. 2021; 76: 497– 509

  • Thinking small: Zinc sensing by the gut epithelium
    Fernández-Gallego N., Sánchez-Madrid, F. and Jimenez-Saiz, R. Allergy. 2021; 76: 411-413

  • Tape strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin
    Pavel A. B., Renert- Yuval, Y., Wu, J., et al. Allergy. 2021; 76: 314- 325

  • Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort
    Gonzalez T., Stevens, M. L., Baatyrbek Kyzy, A., et al. Allergy. 2021; 76:302- 313

  • RV-C infections result in greater clinical symptoms and epithelial responses compared to RV-A infections in patients with CRS
    Willis, A.L., Calton, J.B., Calton, J., et al.Allergy.2020; 75: 3264-3267

  • Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation
    Saunders, SP, Floudas, A, Moran, T, et al. Allergy. 2020; 75: 3216– 3227

  • Impaired airway epithelial cell wound-healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze
    Andersson, CK, Iwasaki, J, Cook, J, et al. Allergy. 2020; 75: 3195– 3207

  • ST2 expression and release by the bronchial epithelium is downregulated in asthma
    Kaur, D, Chachi, L, Gomez, E, et al. Allergy. 2020; 75: 3184– 3194

  • Advances and novel developments in mechanisms of allergic inflammation
    Han, X, Krempski, JW, Nadeau, K. et al. Allergy. 2020; 75: 3100– 3111

  • Skin pH–dependent Staphylococcus aureus abundance as predictor for increasing atopic dermatitis severity
    Hülpüsch, C, Tremmel, K, Hammel, G, et al. Allergy. 2020; 75: 2888– 2898

  • Integration of metagenomics-metabolomics reveals specific signatures and functions of airway microbiota in mite-sensitized childhood asthma
    Chiu, C-Y, Chou, H-C, Chang, L-C, et al. Allergy. 2020; 75: 2846– 2857

  • Integrated mRNA and microRNA transcriptome profiling during differentiation of human nasal polyp epithelium reveals an altered ciliogenesis
    Callejas-Díaz, B, Fernandez, G, Fuentes, M, et al. Allergy. 2020; 75: 2548– 2561

  • The neuroimmunological toll of nutrient absorption
    De Palma, G., Caminero, A. and Jiménez-Saiz, R. Allergy. 2020; 75: 2415-2417

  • Contrasting microbiotas between Finnish and Estonian infants: Exposure to Acinetobacter may contribute to the allergy gap
    Ruokolainen, L, Parkkola, A, Karkman, A, et al. Allergy. 2020; 75: 2342– 2351

  • Human airway epithelial cells express a functional IL-5 receptor
    Barretto, K.T., Brockman-Schneider, R.A., Kuipers, I., et al. Allergy.2020; 75: 2127-2130

  • Mining the infant gut microbiota for therapeutic targets against atopic disease
    Boutin, R.C.T., Sbihi, H., Dsouza, M., et al.Allergy.2020; 75: 2065-2068

  • ORMDL3 but not neighboring 17q21 gene LRRC3C is expressed in human lungs and lung cells of asthmatics
    Hur, G.Y., Pham, A., Miller, M., et al. Allergy.2020; 75: 2061-2065

  • The international sinonasal microbiome study: A multicentre, multinational characterization of sinonasal bacterial ecology
    Paramasivan, S, Bassiouni, A, Shiffer, A, et al. Allergy. 2020; 75: 2037– 2049

  • Antibiotic use during pregnancy increases offspring asthma severity in a dose-dependent manner
    Alhasan, MM, Cait, AM, Heimesaat, MM, et al. Allergy. 2020; 75: 1979– 1990

  • Epithelial cell dysfunction, a major driver of asthma development
    Heijink, IH, Kuchibhotla, VNS, Roffel, MP, et al. Allergy. 2020; 75: 1902– 1917

  • Comel-Netherton syndrome: A local skin barrier defect in the absence of an underlying systemic immunodeficiency
    Stuvel, K, Heeringa, JJ, Dalm, VASH, et al. Allergy. 2020; 75: 1710– 1720

  • Gut microbiota in wheezing preschool children and the association with childhood asthma
    Bannier, M.A.G.E., van Best, N., Bervoets, L., Savelkoul, P.H.M., et al. Allergy.2020; 75: 1473-1476

  • Effects of cryopreservation on antiviral responses of primary airway epithelial cells
    Taka, S., Nikopoulou, C., Polyzos, A., et al. Allergy.2020; 75: 1486-1489

  • Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation
    Kortekaas Krohn, I, Seys, SF, Lund, G, et al. Allergy. 2020; 75: 1155– 1164

  • Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus-predominant subgroup
    Diver, S, Richardson, M, Haldar, K, et al. Allergy. 2020; 75: 808– 817

  • Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma
    Moon, H-G, Kim, S-J, Lee, MK, et al. Allergy. 2020; 75: 357– 369

  • Human airway epithelial extracellular vesicle miRNA signature is altered upon asthma development
    Bartel, S, La Grutta, S, Cilluffo, G, et al. Allergy. 2020; 75: 346– 356

  • Postnatal probiotics and allergic disease in very preterm infants: Sub-study to the ProPrems randomized trial
    Plummer, EL, Chebar Lozinsky, A, Tobin, JM, et al. Allergy. 2020; 75: 127– 136

  • Markers of microbial exposure lower the incidence of atopic dermatitis
    Chatenoud, L, Bertuccio, P, Turati, F, et al. Allergy. 2020; 75: 104– 115

  • Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma
    Choi, Y, Kim, Y-M, Lee, H-R, et al. Allergy. 2020; 75: 95– 103

  • The exposome in atopic dermatitis
    Stefanovic, N, Flohr, C, Irvine, AD. Allergy. 2020; 75: 63– 74

  • Toll-like receptor 2 stimulation augments esophageal barrier integrity
    Ruffner, MA, Song, L, Maurer, K, et al. Allergy. 2019; 74: 2449– 2460

  • Direct assessment of skin epithelial barrier by electrical impedance spectroscopy
    Rinaldi, AO, Morita, H, Wawrzyniak, P, et al. Allergy. 2019; 74: 1934– 1944

  • Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β
    Schwartz, C, Moran, T, Saunders, SP, et al. Allergy. 2019; 74: 1920– 1933

  • Transient epidermal barrier deficiency and lowered allergic threshold in filaggrin‐hornerin (FlgHrnr−/−) double‐deficient mice
    Rahrig, S, Dettmann, JM, Brauns, B, et al. Allergy. 2019; 74: 1327– 1339

  • Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells
    Zhou, X, Wei, T, Cox, CW, Jiang, Y, Roche, WR, Walls, AF. Allergy. 2019; 74: 1266– 1276

  • High levels of butyrate and propionate in early life are associated with protection against atopy
    Roduit, C, Frei, R, Ferstl, R, et al. Allergy. 2019; 74: 799- 809

  • BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL-33 production
    Xiong, Y, Cui, X, Li, W, et al. Allergy. 2019; 74: 495– 506